Vitamin D in cutaneous carcinogenesis : Part I - 12/10/12

Doi : 10.1016/j.jaad.2012.05.044

Jean Y. Tang, MD, PhD ^a,^⁎ , Teresa Fu, MD ^a, Christopher Lau, BA ^b, Dennis H. Oh, MD, PhD ^c,^d, Daniel D. Bikle, MD, PhD ^c,^d,^e, Maryam M. Asgari, MD, MPH ^b,^c
^a Department of Dermatology, Stanford University, Stanford, California
^b Division of Research, Kaiser Permanente Northern California, Oakland, California
^c Department of Dermatology, University of California at San Francisco, California
^d Northern California Institute for Research and Education, San Francisco Veterans Affairs Medical Center, San Francisco, California
^e Department of Medicine, University of California at San Francisco, California

Reprint requests: Jean Y. Tang, MD, PhD, Department of Dermatology, Stanford University, 450 Broadway, Pavilion C, MC 5334, Redwood City, CA 94305.

Abstract

Skin cancer is the most common cancer in the United States. Exposure to ultraviolet radiation is a known risk factor for skin cancer but is also the principal means by which the body obtains vitamin D. Several studies have suggested that vitamin D plays a protective role in a variety of internal malignancies. With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar protective effect. These noncalcemic actions of vitamin D have called into question whether the current recommended intake of vitamin D is too low for optimal health and cancer prevention. Part I will review the role of vitamin D in the epidermis; part II will review the role of vitamin D in keratinocyte-derived tumors to help frame the discussion on the possible role of vitamin D in the prevention of skin cancer.

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Key words : 25(OH)D levels, cholecalciferol, supplements, vitamin D, ultraviolet radiation

Abbreviations used : 1,25(OH)₂D, 25(OH)D, BMI, IOM, IU, NMSC, RDA, SPF, UV, UVB, VDR, VDBP

Plan

Photoprotection and vitamin D levels

Supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases grants K23 AR 051037-01 (Dr Asgari) and K23 AR 056736-01 (Dr Tang) and the Damon Runyon Clinical Investigator Award (Dr Tang).