The 7th edition AJCC staging system for cutaneous squamous cell carcinoma accurately predicts risk of recurrence for heart and lung transplant recipients - 12/10/12
Reprint requests: Sarah T. Arron, MD, PhD, Dermatologic Surgery and Laser Center, University of California at San Francisco, 1701 Divisadero St, Third Floor, Box 316, San Francisco, CA 94115.Abstract |
Background |
Cutaneous squamous cell carcinoma (cSCC) is the most common malignancy after solid organ transplantation, with an increased risk of recurrence and metastasis over the general population. The newly updated 7th edition American Joint Committee on Cancer (AJCC) staging system for cSCC is based on consensus expert opinion and requires validation in large cohort studies and in specific patient subpopulations.
Objective |
Our objective was to evaluate the risk of cSCC recurrence in a high-risk population of heart and lung transplant recipients, based on the 7th edition AJCC staging system.
Methods |
We performed a 10-year retrospective cohort study of all primary cSCC diagnosed in heart and lung transplant recipients at a tertiary care academic dermatology center.
Results |
The cumulative incidence of local recurrence was 4% for cSCC in situ and 19% for stage I cSCC at 5 years, and 54% for stage II cSCC at 3 years. Stage II tumors had a 10-fold greater risk of recurrence than stage I, and a 43-fold greater risk of recurrence than in situ tumors.
Limitations |
This study is limited to a specific patient subgroup at a tertiary care center, and may not be generalizable to all populations.
Conclusions |
Heart and lung transplant recipients are at high risk for local recurrence of cSCC. These data substantiate the prognostic accuracy of the newly updated 7th edition AJCC staging system for stage 0, I, and II cSCC in this population and demonstrate the aggressive behavior of this cancer in immunosuppressed patients.
Le texte complet de cet article est disponible en PDF.Key words : heart transplantation, lung transplantation, squamous cell carcinoma, staging
Abbreviations used : AJCC, cSCC, DM, LR, NCCN, NM, NMSC
Plan
| Supported by National Institutes of Health/National Center for Research Resources/Office of the Director University of California at San Francisco-Clinical and Translational Sciences Institute grant number KL2 RR024130 (Dr Arron). The funding agency played no role in the collection, analysis, interpretation, or publication of these data. |
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| Conflicts of interest: None declared. |
Vol 67 - N° 5
P. 829-835 - novembre 2012 Retour au numéro
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