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Gynécologie Obstétrique & Fertilité
Volume 40, n° 12
pages 784-786 (décembre 2012)
Doi : 10.1016/j.gyobfe.2012.09.005
Received : 20 April 2012 ;  accepted : 18 July 2012
Exposition anténatale au diéthylstilbestrol et cancer du sein
Prenatal diethylstilbestrol exposure and breast cancer

S. Frigo , C. Malina, C. Mathelin
Unité de sénologie, pôle de gynécologie-obstétrique, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France 

Auteur correspondant.

Le diéthylstilbestrol (DES) est un estrogène de synthèse prescrit pour la prévention des fausses couches jusqu’en 1977. Son rôle dans le développement d’adénocarcinomes vaginaux et de dysplasies cervicales est connu et le dépistage codifié. Des études de cohortes récentes montrent que l’exposition in utero au DES entraîne un sur-risque de cancer du sein, notamment après 40ans. Cet article relate l’observation d’un cancer du sein d’une exceptionnelle gravité chez une patiente exposée in utero au DES. Il détaille les risques de cancer du sein pour les « filles DES » tout en proposant des modalités de dépistage.

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Diethylstilbestrol (DES) is a synthetic estrogen prescribed to prevent miscarriages until 1977. Its role in the development of vaginal adenocarcinoma and cervical dysplasia is known and screening codified. Recent cohort studies show that exposure to DES in utero increases breast cancer risk especially after 40years. This article reports the observation of a breast cancer of exceptional gravity in a patient exposed to DES in utero . It details the risk of breast cancer for “DES daughters” and support possible screening modalities.

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Mots clés : Cancer du sein, Dépistage, Diéthylstilbestrol, Exposition in utero

Keywords : Breast cancer, Diethylstilbestrol, In utero exposure, Screening

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