Lack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis: A meta-analysis - 05/12/12

Doi : 10.1016/j.jbspin.2012.02.012

Wang-Dong Xu ^{^{1
Wang-Dong and Shan-Shan Liu contributed equally to this work and should be considered co-first authors.}}, Shan-Shan Liu ^{^{1
Wang-Dong and Shan-Shan Liu contributed equally to this work and should be considered co-first authors.}}, Hai-Feng Pan, Dong-Qing Ye ^⁎
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81, Meishan Road, Hefei, 230032 Anhui, PR China

Corresponding author. Tel.: +86 551 5167726; fax: +86 551 5161171.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

pages	4
Iconographies	0
Vidéos	0
Autres	0

Abstract

Objective

The aim of the study was to determine whether polymorphisms of toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

Methods

A meta-analysis was conducted on the association between the D299G/T399I polymorphisms and RA/AS (when available) using (1) the allelic contrast, (2) the recessive, (3) the dominant, and (4) the additive models.

Results

A total of eleven relevant studies met the inclusion criteria were identified, including RA:

D299G (six studies), T399I (three studies); AS: D299G (five studies), T399I (four studies). Meta-analysis was performed with fixed/random effect models. Overall, no significant RA/AS risk was found in all genetic models when all studies were pooled into the meta-analysis (P>0.05).