Kimura’s disease and Behcet’s syndrome in the same family – are they associated? - 26/01/13
, Isabelle Touitou b, Yakov Fellig c, Mouna Barat-Houari b
Corresponding author. Tel.: +97 226 777 111; fax: +97 226 777 394.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 4 |
| Iconographies | 3 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Background |
Behcet’s disease (BD) and Kimura’s disease (KD) are two inflammatory diseases commonly found in Japan. In Israel, both diseases are quite rare. Recently, we encountered a family whose three siblings suffer from BD and an additional brother suffers from KD. This observation raised the question as to whether both diseases have a common underlying genetic basis.
Aim of the study |
To describe this unique family and to search for possible common alleles in the IL10 gene between BD and KD, as several SNPs in this gene are known to be associated with BD.
Methods |
Three BD siblings and their brother with KD were interviewed and examined. Genomic DNA was prepared from blood samples taken from all nine members of the family. The DNA was genotyped for sequence variations of six SNPs on the IL10 gene.
Results |
The IL10 SNPs did not segregate with BD and KD suggesting that there was no association between the IL10 gene and these diseases in this family.
Conclusions |
SNPs in the IL10 gene shown to be susceptibility factors in adult BD were not associated with BD in this family. The question regarding a possible common genetic basis for KD and BD requires further investigation.
Le texte complet de cet article est disponible en PDF.Keywords : Behcet’s disease, Kimura disease, IL10
Plan
Vol 80 - N° 1
P. 44-47 - janvier 2013 Retour au numéro
Article précédent
- Anti-cyclic citrullinated peptide (anti-CCP) antibody in juvenile idiopathic arthritis (JIA): Correlations with disease activity and severity of joint damage (a multicenter trial)
- Aziza Omar, Ihab Abo-Elyoun, Hanan Hussein, Mohammad Nabih, Hoda Atwa, Suzan Gad, Yasser Emad
- Incomplete thymic involution in systemic sclerosis and rheumatoid arthritis
- Marine Meunier, Ramin Bazeli, Antoine Feydy, Jean-Luc Drape, André Kahan, Yannick Allanore
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?