Article

5 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates



Journal of the American Academy of Dermatology
Volume 68, n° 3
pages 441-451 (mars 2013)
Doi : 10.1016/j.jaad.2012.05.043
accepted : 30 May 2012
Original Articles

New recommendations for the categorization of cutaneous features of congenital melanocytic nevi
 

Sven Krengel, MD a, , Alon Scope, MD c, d, Stephen W. Dusza, DrPh d, Reinhard Vonthein, Dr b, Ashfaq A. Marghoob, MD d
a Department of Dermatology, University of Lübeck, Lübeck, Germany 
b Institut für Medizinische Biometrie und Statistik, University of Lübeck, Lübeck, Germany 
c Department of Dermatology, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel 
d Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 

Reprint requests: Sven Krengel, MD, Department of Dermatology, University Hospital Schleswig-Holstein, Campus Lübeck, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.
Abstract
Background

The diameter of congenital melanocytic nevi (CMN) has served as the lone criterion for determining risks of adverse outcomes such as melanoma. A standardized description of additional morphologic features is needed.

Objective

We sought to develop a consensus-based standardized categorization of cutaneous features of CMN and to test agreement among experts on the proposed scheme.

Methods

An interdisciplinary group of experts in the field of CMN was surveyed using a detailed questionnaire. Applicability of the expert consensus-based scheme was tested for interobserver agreement.

Results

The principal variable of the consensus-based categorization is CMN size, based on maximal diameter the CMN is projected to attain by adulthood. CMN size categories include: small (<1.5 cm); medium (M1: 1.5-10 cm, M2: >10-20 cm); large (L1: >20-30 cm, L2: >30-40 cm); and giant (G1: >40-60 cm, G2: >60 cm). In addition, number of satellite nevi in the first year of life is categorized into none, 1 to 20, more than 20 to 50, and more than 50 satellites. Additional descriptors of CMN include anatomic localization, color heterogeneity, surface rugousity and presence of hypertrichosis (described as none, moderate, marked), and presence of dermal or subcutaneous nodules (none, scattered, extensive). Assessment of consistency among 3 experts showed moderate to excellent interobserver agreement for categorization of the clinical descriptors (kappa values 0.54-0.93).

Limitations

Applicability of the proposed scheme was tested in a virtual setting and only among experts.

Conclusion

The proposed categorization scheme for CMN was agreed upon by experts and showed good interobserver agreement. Such standardized reporting of patients with CMN facilitates the development of an international clinical database for the study of large and giant CMN.

The full text of this article is available in PDF format.

Key words : classification, color, congenital melanocytic nevus, diameter, hypertrichosis, melanoma, neurocutaneous melanocytosis, nodularity, rugosity

Abbreviations used : CDC, CMN, NCM, PAS

CMN classification : SCMN, MCMN (M1-2), LCMN (L1-2), GCMN (G1-2), mMCMN, S0-3, C0-2, R0-2, N0-2, H0-2



 Funding sources: Nevus Outreach Inc.
 Conflicts of interest: None declared.



© 2012  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline