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Journal of the American Academy of Dermatology
Volume 68, n° 3
pages 452-458 (mars 2013)
Doi : 10.1016/j.jaad.2012.08.005
accepted : 8 August 2012
Original Articles

The rate of melanoma transection with various biopsy techniques and the influence of tumor transection on patient survival
 

Mohsin Mir, MD, C. Stanley Chan, MD, Farhan Khan, MD, MBA, Bhuvaneswari Krishnan, MD, Ida Orengo, MD , Theodore Rosen, MD
Baylor College of Medicine, Houston, Texas 

Reprint requests: Ida Orengo, MD, Baylor College of Medicine, 1977 Butler Blvd, 6th Floor, Houston, TX 77030.
Abstract
Background

Depth of melanoma invasion is critical because it dictates patient treatment and prognosis. Recent reports indicate melanoma transection with initial biopsy does not impact patient survival; however, tumor transection can lead to misdiagnosis and inaccurate staging.

Objective

This study assessed the rate of melanoma transection with various biopsy techniques and the impact of tumor transection on patient survival.

Methods

We conducted a retrospective review of all melanoma cases at our institution between 2000 and 2008. Of the 490 melanoma cases identified, 479 met inclusion criteria for the study. The transection rates of biopsy techniques were determined. Cases of transected tumors were matched with nontransected cases in a retrospective case-control fashion to evaluate survival.

Results

The rate of melanoma transection was 1.5% for excisional biopsies, 4.1% for punch biopsies, and 9.0% for saucerization biopsies. The means of disease-free survival for the control and transected groups were 911 days and 832.7 days, respectively (P value .67). Overall survival for the control group was 1073.7 days versus 1012.4 days for the transected group (P value .72).

Limitations

The study used a select population. The sample size of transected biopsies was limited, in turn limiting the power of the study. Residents performed the majority of biopsies.

Conclusion

Punch and saucerization biopsies were more likely to transect tumors than excisional biopsies. The transection of melanoma did not affect overall disease-free survival or mortality in the population studied.

The full text of this article is available in PDF format.

Key words : malignant melanoma, melanoma transection, saucerization biopsy



 Funding sources: None.
 Conflicts of interest: None declared.



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