Article

Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates



Journal of the American Academy of Dermatology
Volume 68, n° 3
pages 489-492 (mars 2013)
Doi : 10.1016/j.jaad.2012.08.021
accepted : 14 August 2012
Reviews

Remission of psoriasis after allogeneic, but not autologous, hematopoietic stem-cell transplantation
 

Benjamin H. Kaffenberger, MD a, , Henry K. Wong, MD, PhD a, Wael Jarjour, MD b, Leslie A. Andritsos, MD c
a Dermatology, Ohio State University College of Medicine, Columbus, Ohio 
b Rheumatology, Ohio State University College of Medicine, Columbus, Ohio 
c Hematology and Blood and Marrow Transplantation, Ohio State University College of Medicine, Columbus, Ohio 

Reprint requests: Benjamin H. Kaffenberger, MD, Dermatology, Ohio State University, 540 Officenter Place, Gahanna, OH 43216.
Abstract

Hematopoietic stem-cell transplantation (HSCT) has emerged as an effective immunotherapy for several severe autoimmune diseases. A comprehensive search of the existing literature was performed for patients with psoriasis and HSCT. Nineteen patients have been reported to have psoriasis resolution after allogeneic or autologous HSCT. In the allogeneic setting, 10 of 13 were noted to have durable remission of their psoriasis with a mean follow-up of 49 months. Two cases that did reoccur were only transient. Six patients underwent autologous transplantation. Of these, 5 of 6 developed a recurrence of their psoriasis within 2 years. Based on a limited number of patients, psoriasis is likely to remit after allogeneic HSCT, but it is likely to recur after autologous HSCT.

The full text of this article is available in PDF format.

Key words : allogeneic, autologous, bone-marrow transplant, cancer, hematopoietic stem-cell transplantation, immunotherapy, medical dermatology, psoriasis vulgaris



 Funding sources: None.
 Conflicts of interest: None declared.



© 2012  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline
You can move this window by clicking on the headline