Fitzpatrick skin phototype is an independent predictor of squamous cell carcinoma risk after solid organ transplantation - 21/03/13
Abstract |
Background |
Solid organ transplant recipients (OTR) are at an increased risk of developing squamous cell carcinoma (SCC) of the skin after transplantation. In predominantly white cohorts, Fitzpatrick skin type (FST) has been reported to be a risk factor for developing posttransplantation skin cancers.
Objective |
Our goal was to determine if FST is a statistically significant risk factor for the development of SCC after solid organ transplantation in a diverse US population of OTR.
Methods |
A cohort of OTR completed a questionnaire of demographic factors, transplant type, FST, and skin cancer history. Univariate and multivariate analyses were performed to determine the risk factors for development of SCC after transplantation.
Results |
As expected, male subjects had an increased risk for SCC compared with female subjects (P = .02), and those aged 50 years and older at the time of transplantation were more likely to develop SCC compared with those younger than 50 years (P < .001). The risk of SCC increased with each incremental decrease in FST, from FST VI to FST I (linear test for trend P < .001).
Limitations |
Our questionnaire did not ask specifically about immunosuppressive medications; instead, organ transplant category was used as a proxy for level of immunosuppression.
Conclusions |
FST, a patient-reported variable, is an independent risk factor for the development of SCC in OTR, and should be elicited from patients who have gone or will undergo organ transplantation.
Le texte complet de cet article est disponible en PDF.Key words : Fitzpatrick skin type, immunosuppression, organ transplant recipient, phototype, solid organ transplantation, squamous cell carcinoma
Abbreviations used : CI, FST, HR, NMSC, OTR, SCC
Plan
| This publication was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through University of California, San Francisco-Clinical and Translational Science Institute Grant Number KL2 TR000143. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Dr Chren is supported by National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) grant number K24 AR052667. |
|
| Conflicts of interest: None declared. |
Vol 68 - N° 4
P. 585-591 - avril 2013 Retour au numéro
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