The impact of emollients on phototherapy: A review - 18/04/13
Abstract |
When treating psoriasis, various topical emollients exist that can affect the penetration of ultraviolet radiation in phototherapy. Compared with normal-appearing skin with a reflectance of 4% to 5%, psoriatic skin has higher reflectance as a result of its increased air-to-corneocyte interfaces. Studies have tested the effect of emollients on light penetration by assessing psoriatic plaque clearance, differences in minimal erythema dose, and physical properties of the emollient (eg, monochromatic protection factor and absorbance). Psoriatic plaque clearance was found to improve with serous (thin liquid)-based emollients (eg, Vaseline oil [Unilever, Blackfriars, London, UK], mineral oil, and glycerol), whereas clearance decreased with salicylic acid and viscous-based emollients (eg, petrolatum). Emollients with high ultraviolet absorbance properties increased minimal erythema dose, and those with low absorbance properties decreased minimal erythema dose. Interestingly, when a liquid emollient with a refractive index close to that of normal-appearing skin was applied, there was a net increase in light absorption, or a reduction in reflection that exceeded the emollient’s innate ability to absorb light.
Le texte complet de cet article est disponible en PDF.Key words : broadband, emollient, Goeckerman, mineral oil, narrowband, phototherapy, psoriasis, refractive index, skin optics, ultraviolet, Vaseline
Abbreviations used : MED, MPF, nD, SPF, UV
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Funding sources: None. |
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Conflicts of interest: None declared. |
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Disclosure: Dr Koo is a clinical researcher for Abbott, Amgen, PhotoMedex, Pfizer, and Teikoku, and is a speaker and consultant for Leo, Galderma, and Glaxo-Smith-Klein. Dr Asztalos, Ms Heller, and Dr Lee have no conflicts of interest to declare. |
Vol 68 - N° 5
P. 817-824 - mai 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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