Amniotic membrane grafting in patients with epidermolysis bullosa with chronic wounds - 24/04/13
Reprint requests: Elena Pope, MD, MSc, FRCP, University of Toronto, Section of Dermatology, Division of Pediatric Medicine, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8 Canada.Abstract |
Background |
Severe forms of epidermolysis bullosa (EB) are characterized by chronic, nonhealing wounds.
Objective |
We sought to evaluate the usefulness of amniotic membranes in patients with EB.
Methods |
A retrospective chart review of patients with EB who were treated with amniotic membranes (two patients, 8 applications) was conducted. The primary outcome measure was number of days to complete healing, and the secondary outcome measures were a qualitative wound score, a visual analog scale score, and potential adverse effects.
Results |
The number of days to detect a significant clinical response, defined as greater than 50% improvement, was 40.3 ± 21.2 days. The median qualitative wound score was 2 (range 0-5). The mean visual analog scale score at last follow-up was 31.4 ± 26.8. No adverse events were noted.
Limitations |
Retrospective design, healing assessed by comparing photographs, and partial grafting of some wounds were limitations.
Conclusion |
This proof-of-concept study revealed the potential usefulness of amniotic membrane grafting in promoting healing of chronic wounds in patients with EB
Le texte complet de cet article est disponible en PDF.Key words : amniotic membrane, biological dressing, chronic wounds, epidermolysis bullosa
Abbreviations used : AM, EB, RDEB, VAS
Plan
| Funding sources: None. |
|
| Conflicts of interest: None declared. |
Vol 62 - N° 6
P. 1038-1044 - juin 2010 Retour au numéro
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