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Journal of the American Academy of Dermatology
Volume 62, n° 6
pages 1050-1052 (juin 2010)
Doi : 10.1016/j.jaad.2009.01.029
Case Report

Rosaceiform dermatitis associated with topical tacrolimus treatment

Shoko Fujiwara, MD, Yukari Okubo, MD , Ryokichi Irisawa, MD, Ryoji Tsuboi, MD
Department of Dermatology, Tokyo Medical University, Tokyo, Japan 

Reprint requests: Yukari Okubo, MD, Department of Dermatology, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 166-0023, Japan.

We describe herein 3 patients who developed rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus ointment for facial dermatitis. Skin biopsy specimens showed telangiectasia and noncaseating epithelioid granulomatous tissue formation in the papillary to mid dermis. Continuous topical use of immunomodulators such as tacrolimus or pimecrolimus should be regarded as a potential cause of rosaceiform dermatitis, although many cases have not been reported.

The full text of this article is available in PDF format.

Key words : rosaceiform dermatitis, tacrolimus treatment

 Funding sources: None.
 Conflicts of interest: None declared.

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