4 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

Journal of the American Academy of Dermatology
Volume 62, n° 6
pages 995-1004 (juin 2010)
Doi : 10.1016/j.jaad.2009.06.082
accepted : 25 June 2009

High numbers of DC-SIGN+ dendritic cells in lesional skin of cutaneous T-cell lymphoma

Christoph Schlapbach, MD, André Ochsenbein, MD, Ursula Kaelin, MD, Akmal S. Hassan, MD, Robert E. Hunger, MD, PhD , Nikhil Yawalkar, MD
Department of Dermatology, University of Bern, Bern, Switzerland 

Reprint requests: Robert Hunger, MD, PhD, Department of Dermatology, University of Bern, Inselspital, 3010 Bern, Switzerland.

The role of dendritic cells (DCs) in disease progression of primary cutaneous T-cell lymphoma (CTCL) is not well understood. With their unique ability to induce primary immune responses as well as immunotolerance, DCs play a critical role in mediation of anti-tumor immune responses. Tumor-infiltrating DCs have been determined to represent important prognostic factors in a variety of human tumors.


To date, only circulating DC populations have been investigated in CTCL. Therefore we analyzed the expression and tissue distribution of different DC subset markers in lesional and nonlesional skin of patients with CTCL.


Twelve patients with mycosis fungoides or Sézary syndrome were included in the study. Tissue samples were obtained from lesional and nonlesional skin as a control. Immunohistochemistry was performed with different DC subset and regulatory T-cell markers and assessed using a digital image analysis system. Tissue distribution of DCs in relation to the tumor was analyzed by double immunofluorescence.


We found a significant infiltration of CTCL lesions by immature CD209/DC-SIGN+ DCs with close contact to tumor cells. Matured and activated DCs were only rarely detected in lesions of CTCL.


The sample size was small.


The preponderance of immature CD209/DC-DIGN+ DCs in contact with regulatory T cells in lesions of CTCL points to an important role of this subset in the host’s immune reaction to the malignant T cells. Since these immature DCs are known to induce immunotolerance, they might play a role in the mediation of immune escape of the proliferating clone.

The full text of this article is available in PDF format.

Key words : CTCL, cutaneous T-cell lymphoma, DC-SIGN/CD209, dendritic cell, dendritic cell subsets, mycosis fungoides, Sézary syndrome, tumor immunology

Abbreviations used : CD, CTCL, DC, IL, MUC1, T reg

 Dr Hassan is currently with the Department of Dermatology, Cairo University, 11559-Cairo, Egypt.
 Supported by the Bernische Krebsliga, Bern.
 Conflicts of interest: None declared.

© 2009  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline