Tissue gadolinium deposition and fibrosis mimicking nephrogenic systemic fibrosis (NSF)–subclinical nephrogenic systemic fibrosis? - 24/04/13
Abstract |
Nephrogenic systemic fibrosis is a condition with significant and often debilitating cutaneous manifestations. Recent research on this disease has delineated an association between nephrogenic systemic fibrosis and exposure to magnetic resonance imaging studies using gadolinium-based contrast agents in patients with ongoing renal failure. This metal has been detected in cutaneous biopsy specimens taken from lesional skin suggesting that gadolinium provides an impetus for the deposition of circulating fibrocytes in the skin and subsequent fibrosis. We describe a hemodialysis-dependent liver transplant recipient who received a gadolinium-based contrast agent and demonstrated insoluble gadolinium deposition in a fibrotic dermis and subcutaneous septum using scanning electron microscopy/energy dispersive x-ray spectroscopy. He has yet to manifest symptoms and signs of nephrogenic systemic fibrosis 3 years after his magnetic resonance imaging study.
Le texte complet de cet article est disponible en PDF.Key words : gadolinium, leg ulcer, nephrogenic systemic fibrosis
Abbreviations used : CF, GBCA, Gd, MRI, NSF
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 62 - N° 2
P. 337-342 - février 2010 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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