Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation - 24/04/13
, Hideyuki Iida, MD a, Takaya Fukumoto, MD, PhD a, Nobuhiko Kobayashi, MD, PhD a, Hironori Niizeki, MD, PhD a, Takeshi Morii, MD, PhD b, Hiroshi Kimura, MD, PhD b, Sachiko Miyagawa, MD, PhD a
Reprint requests: Hideo Asada, MD, PhD, Department of Dermatology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.Abstract |
Background |
The relationship between herpesvirus reactivation and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) is unclear.
Objective |
We sought to examine the relationship between human herpesvirus (HHV) reactivation and rash/GVHD after allo-SCT by prospective evaluation.
Methods |
Fifteen patients who had received allo-SCT underwent prospective serial examinations for human herpesvirus 6 (HHV-6), HHV-7, cytomegalovirus, and Epstein-Barr virus DNA in the blood by polymerase chain reaction and real-time polymerase chain reaction. Serum interferon gamma, interleukins 4 and 10, tumor necrosis factor alpha, and soluble interleukin 2 receptor (sIL-2R) were also measured.
Results |
In 10 of 15 patients, macular/papular eruptions were seen after allo-SCT and GVHD was diagnosed. In 8 patients with rash, HHV-6 DNA levels correlated with the cutaneous manifestation. Interleukin 10 and sIL-2R also increased in association with rash.
Limitations |
The number of patients in our study was relatively small. Not all patients were examined for cytokines and sIL-2R.
Conclusions |
HHV-6 reactivation may be involved in the pathogenesis of rash/GVHD after allo-SCT.
Le texte complet de cet article est disponible en PDF.Abbreviations used : allo-SCT, CMV, EBV, GVHD, HHV, IFN, IL, PCR, RISCT, SCT, sIL-2R, TNF
Plan
| Funding sources: Health and Labour Sciences Research Grant (Research on Intractable Diseases). |
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| Conflicts of interest: None declared. |
Vol 58 - N° 5
P. 802-809 - mai 2008 Retour au numéro
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