Abortive or minimal-growth hemangiomas: Immunohistochemical evidence that they represent true infantile hemangiomas - 24/04/13
Abstract |
Background |
Infantile hemangiomas have a characteristic natural history of rapid proliferation in the first weeks of life followed by spontaneous involution. At birth, they may be present as a precursor lesion. Sometimes one may see precursor lesions that never undergo a growth phase or that undergo minimal growth. It is unclear the exact nature of these precursor-like lesions.
Objective |
We sought to describe the morphology and histopathology of these precursor-like lesions.
Methods |
We describe 4 patients with macules resembling precursor lesions of hemangiomas that did not show proliferation phase or minimal growth. The histopathologic and immunohistochemical study with glucose transporter-1 was performed in all of these cases.
Results |
The skin biopsy specimen showed superficial ectatic vessels that reacted with anti-glucose transporter-1 antibodies. All skin biopsy specimens exhibited capillary lobules in papillary dermis and, in two of them, in the reticular dermis and subcutis.
Limitations |
This text is limited by the number of cases reported.
Conclusions |
Precursor lesions of hemangioma that do not show proliferation phase or minimal growth represent, in the view of glucose transporter-1 immunoreactivity, true hemangiomas of infancy with an aborted or arrested growth cycle.
Le texte complet de cet article est disponible en PDF.Abbreviations used : GLUT, IH, NICH
Plan
Funding sources: None. |
|
Conflicts of interest: None declared. |
Vol 58 - N° 4
P. 685-690 - avril 2008 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?