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Journal of the American Academy of Dermatology
Volume 63, n° 3
pages 507-525 (septembre 2010)
Doi : 10.1016/j.jaad.2009.07.037

Vitamins and photoaging: Do scientific data support their use?

Jamie Zussman, MD a, Jennifer Ahdout, MD a, Jenny Kim, MD, PhD a, b,
a Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 
b Department of Dermatology, Greater Los Angeles Healthcare System Veterans Affairs, Los Angeles, California 

Reprint requests: Jenny Kim, MD, PhD, Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, 52-121 Center for the Health Sciences, 10833 Le Conte Ave, Los Angeles, CA 90095-1750.

With the rise of the cosmeceutical industry, numerous formulations have surfaced with claims of reducing the clinical manifestations of photoaging. Many of these products capitalize on the positive connection the public makes with vitamins, especially with respect to their antioxidant capabilities. An impressive amount of basic science and clinical research has been conducted in both an attempt to discover novel strategies for preventing detrimental sun damage and to validate the addition of vitamins to skin care products. As dermatologists, it will be essential to provide our patients with substantiated counseling regarding the efficacy of commercial assertions. In this review, we will systematically examine the evidence supporting the use of vitamins in oral and topical formulations and provide a brief summary of the pathogenesis of photoaging. Limitations of this study include that there may be unpublished data or additional studies that may have been overlooked in our comprehensive review of this topic.

The full text of this article is available in PDF format.

Key words : antioxidant, ascorbic acid, niacin, niacinamide, pharmaceutical, photoaging, retinoid, tocopherol, ultraviolet, vitamin

Abbreviations used : FDA, MED, MMP, NAD, RAR, ROS, UV

 Funding sources: None.
 Disclosure: Dr Kim is a consultant for Allergan, Galderma, J&J, Stiefel, and Medicis, which manufacture retinoid analogues discussed in this article. Drs Zussman and Ahdout have no conflicts of interest to declare.

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