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Journal of the American Academy of Dermatology
Volume 63, n° 2
pages 266-273 (août 2010)
Doi : 10.1016/j.jaad.2009.08.056
accepted : 14 August 2009
Original Articles

Long-term follow-up study of clear cell papulosis
 

Fang-Wen Tseng, MD a, Tseng-Tong Kuo, MD, PhD b, c, Pei-Hsuan Lu, MD a, c, Heng-Leong Chan, MD d, Ming-Jing Chan, MD a, c, Rosaline Chung-Yee Hui, MD, PhD a, c,
a Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan 
b Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan 
c Chang Gung University College of Medicine, Taipei, Taiwan 
d Department of Dermatology, Sutein Clinic, Taipei, Taiwan 

Reprint requests: Rosaline Chung-Yee Hui, MD, PhD, Department of Dermatology, Chang Gung Memorial Hospital, No. 199, Tung-Hwa North Road, Taipei, Taiwan.
Abstract
Background

Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown.

Objectives

The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome.

Methods

Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed.

Results

With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density.

Limitations

Retrospective nature of the study is a limitation.

Conclusion

No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression.

The full text of this article is available in PDF format.

Key words : clear cell papulosis, clear cells of Toker, extramammary Paget disease, long-term follow-up, milk line

Abbreviations used : CCP, CEA, EMA, EMPD, MPD, PAS



 Funding sources: None.
 Conflicts of interest: None declared.



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