A case-control study of polymorphic eruption of pregnancy - 24/04/13
, Virginie Fermand, CNM b, Pierre Levy, MD c, Serge Uzan, MD b, Selim Aractingi, MD a
Reprint requests: Stephanie Regnier, MD, Pavillon Tarnier-Hôpital Cochin, 89 rue d’Assas, 75006 Paris, France.Abstract |
Background |
Polymorphic eruption of pregnancy (PEP) is a pruritic disease that usually occurs in primiparous women, most commonly in the last trimester of pregnancy. The origin and pathomechanisms still remain unknown.
Objectives |
We attempted to determine the parameters that may be associated with or complicate the course of PEP.
Methods |
Data of 200 pregnant women (40 PEP and 160 control) were studied retrospectively and compared statistically using univariable and multivariable analysis.
Results |
In multivariate analysis, pregnancy with male fetuses (P = .02) and delivery by cesarean section (P = .012) were overrepresented in the PEP group. A tendency toward more multiple gestation pregnancy in PEP was found (P = .07). The risk of PEP was not related to excessive maternal or fetal weight gain.
Limitations |
This was a retrospective study.
Conclusion |
This large case-control study confirms the already suspected association of PEP with male fetuses and cesarean deliveries in multivariate analysis. The higher rate of multiple gestation pregnancy was also established.
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| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 58 - N° 1
P. 63-67 - janvier 2008 Retour au numéro
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