A report of Epstein-Barr virus–positive primary cutaneous natural killer–/T-cell lymphoma - 24/04/13
Abstract |
We describe a patient who presented with Epstein-Barr virus–positive tumor-stage primary cutaneous lymphoma. Our patient had previously been treated with oral methotrexate for long-standing rheumatoid arthritis. Tissue analysis revealed large tumor cells that were surface CD2- and CD3-positive; T-cell–restricted intracellular antigen–positive; CD56-, CD20-, and CD30-negative; and stained positively for Epstein-Barr virus. Our case is noteworthy for several reasons. Although the presence of rheumatoid arthritis and therapy with methotrexate are putative risk factors for the development of immune suppression-related and Epstein-Barr virus–related lymphomas, the vast majority of lymphomas in this setting are of B-cell origin, and rarely are these primary cutaneous in nature. In addition, our patient’s tumor displayed an unusual phenotype, with immunophenotypic features suggestive of an atypical natural killer–/T-cell lymphoma. Methotrexate was withdrawn, and our patient was successfully treated with local radiotherapy. She has remained in complete remission 28 months since diagnosis.
Le texte complet de cet article est disponible en PDF.Abbreviations used : EBV, MTX, NK, RA, TNF
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 59 - N° 1
P. 157-161 - juillet 2008 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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