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Journal of the American Academy of Dermatology
Volume 58, n° 2
pages 217-223 (février 2008)
Doi : 10.1016/j.jaad.2007.09.039
accepted : 19 September 2007
Comparison of histopathologic–clinical characteristics of Jessner’s lymphocytic infiltration of the skin and lupus erythematosus tumidus: Multicenter study of 46 cases
 

Valérie Rémy-Leroux, MD a, Fabienne Léonard, MD a, Daniel Lambert, MD b, Janine Wechsler, MD c, Bernard Cribier, MD, PhD d, Pierre Thomas, MD e, Henri Adamski, MD f, Marie-Claude Marguery, MD, PhD g, François Aubin, MD, PhD h, Dominique Leroy, MD i, Philippe Bernard, MD, PhD a,
a Service de Dermatologie, Hôpital Robert-Debré, Centre Hospitalier de Reims, Reims, France 
b Service de Dermatologie, Hôpital du Bocage, Centre Hospitalier de Dijon, Dijon, France 
c Service d’Anatomopathologie, Hôpital Henri Mondor, Centre Hospitalier de Créteil, Créteil, France 
d Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France 
e Clinique Dermatologique, Centre Hospitalier de Lille, Lille, France 
f Service de Dermatologie, Hôpital Pontchaillou, Centre Hospitalier de Rennes, Rennes, France 
g Service de Dermatologie, Hôpital Purpan, Centre Hospitalier de Toulouse, Toulouse, France 
h Service de Dermatologie, Hôpital St Jacques, Centre Hospitalier de Besançon, Besançon, France 
i Service de Dermatologie, Hôpital Clémenceau, Centre Hospitalier de Caen, Caen, France 

Correspondence to: Philippe Bernard, MD, PhD, Centre Hospitalier de Reims, Hôpital Robert-Debré, Service de Dermatologie, avenue du Général Koenig, 51092 Reims Cedex, France.
Abstract
Objective

We sought to identify criteria able to distinguish between Jessner’s lymphocytic infiltration of the skin (JLIS) and lupus erythematosus tumidus (LET).

Methods

The following characteristics were recorded in a retrospective, multicenter analysis of patients with JLIS and LET: clinical features (number, size, type, and localization of lesions; photosensitivity; extracutaneous signs), histologic findings, phototesting, lupus serology, treatment, and outcome. Available histologic slides were reviewed blinded to the initial diagnosis using a pre-established grid.

Results

Univariate analysis of data from patients with JLIS (15 women, 17 men; mean age: 35 years) and LET (13 women, one man; mean age: 31 years) showed the following significant (P < .05) differences: more frequent back involvement and annular lesions in JLIS, as opposed to female predominance, more frequent face involvement, and plaques in LET. Phototesting, especially ultraviolet B, induced lesions in 18 of 26 patients with JLIS and all 4 with LET. The blinded histologic review (33 samples) only found slight epidermal atrophy and focal thickened dermoepidermal junction more frequent and perivascular lymphocyte infiltrations less dense in LET. The two groups of patients reclassified according histopathologic features (18 LET and 11 JLIS) showed only slight clinical differences (more frequent nasal bridge lesions in LET and annular lesions in JLIS).

Limitation

The retrospective nature of the study is a limitation.

Conclusion

JLIS and LET in this population showed more similarities than differences, supporting a continuous spectrum covering these two entities.

The full text of this article is available in PDF format.

Abbreviations used : CCLE, JLIS, LET, UV



 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.



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