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Journal of the American Academy of Dermatology
Volume 58, n° 2
pages 251-256 (février 2008)
Doi : 10.1016/j.jaad.2007.11.009

Heterotopic salivary gland tissue in the neck

Anna Haemel, MD a, b, Douglas R. Gnepp, MD c, e, James Carlsten, MD d, Leslie Robinson-Bostom, MD e, f,
a Department of Medicine, University of Wisconsin, Madison, Wisconsin 
b Department of Dermatology, University of Wisconsin, Madison, Wisconsin 
c Department of Pathology, the Warren Alpert Medical School of Brown University, Providence, Rhode Island 
f Department of Dermatology, the Warren Alpert Medical School of Brown University, Providence, Rhode Island 
d Anatomic Pathology, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island 
e Department of Pathology, Rhode Island Hospital, Providence, Rhode Island 

Correspondence to: Leslie Robinson-Bostom, MD, Rhode Island Hospital, APC 10, 593 Eddy St, Providence, RI 02903.

Heterotopic salivary gland tissue (HSGT) consists of salivary tissue outside of the major and minor salivary glands and typically presents as a draining sinus and/or asymptomatic nodule of the neck along the lower anterior sternocleidomastoid muscle. There are a limited number of case series exploring this rare entity. To further delineate the clinicopathologic characteristics of this lesion, we present 11 cases of HSGT in the neck, many with cutaneous involvement. Anatomic pathology files from Lifespan-affiliated hospitals (Rhode Island Hospital and Miriam Hospital) were retrospectively reviewed for all cases meeting criteria for HSGT from 1983 through 2005, and 11 patients were identified: 4 female and 7 male, ages 5 months to 64 years, with 8 patients younger than 18 years; 7 patients presented with a draining sinus. Of note, 8 of 11 cases occurred on the right side. In general, microscopic examination revealed mucinous and serous salivary glandular structures with an associated duct; no cytologic atypia was observed. All cases stained positive for smooth muscle actin and calponin, highlighting a myoepithelial layer similar to that seen in minor and major salivary glands. As in our series, most cases of cervical HSGT occur near the anterior sternocleidomastoid muscle with a right-sided predilection. Cases generally present by early childhood, although 3 cases in our series were diagnosed in adulthood. Although cancers arising in these lesions are fairly uncommon, most clinically apparent foci of HSGT are excised. This entity should be considered in the dermatologist’s differential diagnostic considerations for a draining sinus and a lateral, especially right-sided, neck mass.

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Abbreviations used : HSGT, SCM

 Funding sources: None.
 Conflicts of interest: None declared.
 Previously partially presented as a poster at the American Academy of Dermatology Summer Academy Meeting, Chicago, Ill, July 21-3, 2005.
 Reprints not available from the authors.

© 2008  American Academy of Dermatology, Inc.@@#104156@@
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