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Journal of the American Academy of Dermatology
Volume 58, n° 2
pages 290-294 (février 2008)
Doi : 10.1016/j.jaad.2006.12.022
Case & Reviews

Intravascular cytotoxic T-cell lymphoma: A case report and review of the literature

Briana C. Gleason, MD a, , Nooshin K. Brinster, MD b, , Scott R. Granter, MD a, Geraldine S. Pinkus, MD a, Neal I. Lindeman, MD a, Danielle M. Miller, MD, PhD c,
a Department Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 
c Department Dermatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 
b Lahey Clinic, Burlington, Massachusetts 

Correspondence to: Danielle M. Miller, MD, PhD, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115.

Intravascular lymphoma (IVL) is a rare subtype of extranodal diffuse large B-cell lymphoma in the World Health Organization classification. Although the majority of cases are of B-cell lineage, cases of IVL with a T-cell phenotype and, rarely, histiocytic and natural killer (NK)-cell phenotypes have been reported. We report a case of T-cell IVL with a cytotoxic phenotype. A 62-year-old male presented with erythematous patches and plaques on the lower extremities, and a biopsy revealed IVL with an activated cytotoxic phenotype (CD56+, perforin+, granzyme B+, TIA-1+, CD3+, CD20, CD4, CD8, CD5, and T-cell receptor [TCR] βF1-), consistent with either NK-cell or T-cell origin. TCR gene analysis showed a monoclonal T-cell population, supporting the diagnosis of a T-cell IVL. Although the patient’s skin lesions were refractory to combination chemotherapy and salvage chemotherapy regimens, there has been no evidence of disease progression in 24 months of follow-up.

The full text of this article is available in PDF format.

 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.

  These authors contributed equally to this work.

© 2008  American Academy of Dermatology, Inc.@@#104156@@
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