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Journal of the American Academy of Dermatology
Volume 58, n° 2
pages 326-335 (février 2008)
Doi : 10.1016/j.jaad.2007.07.031
Case Reports

Cutaneous sarcoidosis and primary biliary cirrhosis: A chance association or related diseases?
 

Sowmya Kishor, MD a, Maria L. Turner, MD b, Brian B. Borg, MD, MHS c, David E. Kleiner, MD d, Edward W. Cowen, MD, MHSc b,
a Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia 
b Dermatology Branch, National Cancer Institute, Bethesda, Maryland 
d Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 
c Department of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 

Correspondence to: Edward W. Cowen, MD, MHSc, Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bldg 10/Room 12N238, 10 Center Dr, MSC 1908, Bethesda, MD 20892-1908.
Abstract

Sarcoidosis and primary biliary cirrhosis (PBC) are thought to be two distinct disorders of unknown origin. However, both are characterized by hepatic granuloma formation and may also manifest cutaneous granulomatous inflammation. In this report, we describe two cases of cutaneous sarcoidosis occurring in the setting of PBC and review 7 additional cases from the literature of granulomatous skin disease associated with PBC. Although the pathogenesis of both sarcoidosis and PBC remains elusive, the simultaneous occurrence of these uncommon diseases suggests a common pathway may contribute to granuloma formation in both disorders.

The full text of this article is available in PDF format.

 Supported in part by the Intramural Program of the National Institutes of Health, Center for Cancer Research, National Cancer Institute.
 Conflicts of interest: None declared.
 Reprints not available from the authors.



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