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Journal of the American Academy of Dermatology
Volume 58, n° 3
pages 415-420 (mars 2008)
Doi : 10.1016/j.jaad.2007.10.010
Disease severity, scratching, and sleep quality in patients with atopic dermatitis
 

Bruce G. Bender, PhD a, b, , Robert Ballard, MD c, Beth Canono, BS d, James R. Murphy, PhD e, Donald Y.M. Leung, MD, PhD a, f
a Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 
d General Clinical Research Center, National Jewish Medical and Research Center, Denver, Colorado 
e Department of Biostatistics and Bioinformatics, National Jewish Medical and Research Center, Denver, Colorado 
b Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 
f Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 
c HealthOne, Denver, Colorado 

Reprint requests: Bruce G. Bender, PhD, Pediatric Behavioral Health, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206.
Abstract
Background

The relationship between sleep quality and disease severity in patients with atopic dermatitis has not been clearly defined.

Methods

Sleep efficiency and scratching were measured over 2 nights by polysomnography, actigraphy, and self-report in 20 adults with atopic dermatitis. Tumor necrosis factor, interleukin (IL)-6, and IL-10 were assayed from a subset of 9 participants.

Results

Sleep measured by actigraphy and polysomnography were strongly associated with each other. Decreased sleep efficiency was associated with increasing disease severity, scratching, and IL-6. Self-reported sleep quality and quality of life were not significantly correlated with either objective sleep measure.

Limitations

Results in this pilot study await confirmation in a larger investigation.

Conclusion

Objective measures but not self-report documented that increasing severity of atopic dermatitis results in more scratching and declining sleep quality. Our data also suggest an important relationship between sleep and IL-6.

The full text of this article is available in PDF format.

Abbreviations used : AD, IL, PSG, REM, TBSA



 Funding sources: None.
 Conflicts of interest: None declared.



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