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Journal of the American Academy of Dermatology
Volume 58, n° 3
pages 421-429 (mars 2008)
Doi : 10.1016/j.jaad.2007.11.023
accepted : 27 November 2007
Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control study
 

Yolanda B. Brauchli, MSc a, Susan S. Jick, DSc b, François Curtin, MD c, Christoph R. Meier, PhD, MSc a, b,
a Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland 
b Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, Massachusetts 
c Merck Serono SA, Geneva, Switzerland 

Reprint requests: Christoph R. Meier, PhD, MSc, Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Hebelstrasse 2, CH-4031 Basel, Switzerland.
Abstract
Background

Small clinical trials suggest that thiazolidinediones may exert a beneficial effect on skin lesions of patients with psoriasis. Little is known about other classes of antidiabetic drugs and the psoriasis risk.

Objective

We sought to study the association between use of thiazolidinediones, sulfonylureas, biguanides, or acarbose and the risk of developing a first-time diagnosis of psoriasis.

Methods

We conducted a case-control analysis on the United Kingdom–based General Practice Research Database. We identified patients with an incident psoriasis diagnosis from 1994 to 2005 and matched one control subject to each patient on age, sex, general practice, calendar time, and years of history in the database. Conditional logistic regression was used to estimate the odds ratio with 95% confidence intervals (CI) of developing a first-time psoriasis diagnosis in relation to previous exposure to antidiabetic drugs, stratified by exposure timing and duration of use and adjusted for a variety of potential confounders.

Results

We identified 36,702 patients with a first-time psoriasis diagnosis and the same number of matched control subjects. As compared with no use, the adjusted odds ratio for current use of 1 to 4 prescriptions or greater than or equal to 5 prescriptions for thiazolidinediones were 1.01 (95% CI 0.34-3.01) and 0.33 (95% CI 0.16-0.66), respectively. Current use of greater than or equal to 15 prescriptions for metformin or sulfonylureas yielded adjusted odds ratio of 0.77 (95% CI 0.62-0.96) and 1.07 (95% CI 0.88-1.31), respectively.

Limitations

The findings are based on a small number of patients exposed to thiazolidinediones (100 in total, 48 current users of ≥5 prescriptions).

Conclusions

The findings of this large observational study provide further evidence for a potentially beneficial effect of thiazolidinediones on psoriasis. While current long-term use of metformin was also associated with a suggestion of a reduced psoriasis risk, no such effect was seen for use of other oral antidiabetics.

The full text of this article is available in PDF format.

Abbreviations used : BMI, CI, GP, GPRD, IL, OR, PPAR



 Supported by an unrestricted grant from Merck Serono, Switzerland, and by a grant from the Senglet Foundation, Switzerland (Ms Brauchli).
 Conflicts of interest: None declared.



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