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Journal of the American Academy of Dermatology
Volume 58, n° 3
pages 458-471 (mars 2008)
Doi : 10.1016/j.jaad.2007.12.006
accepted : 4 December 2007
Pathogenesis of calciphylaxis: Hans Selye to nuclear factor κ-B

Roger H. Weenig, MD, MPH
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 

Reprint requests: Roger H. Weenig, MD, MPH, Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

The clinical syndrome of calciphylaxis is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, necrotic skin ulceration, and a high mortality rate. This review integrates calciphylaxis risk factors with the molecular processes governing osseous and extraosseous mineralization. As the pathogenesis of calciphylaxis is better understood, targeted therapies aimed at disease prevention and reversal will follow.

The full text of this article is available in PDF format.

Abbreviations used : BMP, Cbfa, CPP, ET, IL, MGP, NFκB, OPG, PTH, RANK, RANKL, TNF

 Funding sources: None.
 Conflicts of interest: None declared.

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