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Journal of the American Academy of Dermatology
Volume 58, n° 3
pages 490-493 (mars 2008)
Doi : 10.1016/j.jaad.2007.06.030
Case Reports

Localized involutional lipoatrophy with epidermal and dermal changes

Ossama Abbas, MD, Salah Salman, MD, Abdul Ghani Kibbi, MD, Adele Chedraoui, MD, Samer Ghosn, MD
Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon 

Reprint requests: Samer Ghosn, MD, Department of Dermatology, American University of Beirut Medical Center, Riad El Solh St, PO Box 11-0236, Beirut, Lebanon.

Localized involutional lipoatrophy (LIL) was first described in 1986 as a distinctive idiopathic form of localized lipoatrophy characterized by loss of adipose tissue without antecedent inflammation. Clinically, LIL usually presents as a solitary, asymptomatic, well-demarcated, atrophic depression and often involves areas of antecedent intramuscular or intra-articular injections. Histologically, changes in the subcutaneous fat in LIL resemble fetal adipose tissue. Only rarely has there been any description of epidermal or dermal changes occurring with LIL. We describe two cases of LIL with overlying hypopigmentation and atrophy, and with morphea-like changes on histology. Recognition of these changes may have clinical and diagnostic implications.

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 Funding sources: None.
 Conflicts of interest: None declared.

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