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Journal of the American Academy of Dermatology
Volume 58, n° 3
pages 505-507 (mars 2008)
Doi : 10.1016/j.jaad.2007.03.034
Case Reports

Ichthyosis cribriformis: A new entity?
 

Hiram Larangeira de Almeida, MD a, , Rudolf Happle, MD b, Ulrike Blume-Peytavi, MD c, Luis Antônio Suita de Castro, MSc d
a Catholic and Federal University of Pelotas, Pelotas, Brazil 
b Philipp University of Marburg, Marburg, Germany 
c Department of Dermatology and Allergy Charité-Universitätsmedizin Berlin, Berlin, Germany 
d Laboratory for Electron Microscopy, EMBRAPA-CPA-CT, Pelotas, Brazil 

Reprint requests: Hiram Larangeira de Almeida Jr, MD, Mestrado em Saúde e Comportamento–UCPEL, Rua Barroso 1202–107, 96010-280 Pelotas RS Brazil.
Abstract

A 22-year-old woman had an unusual congenital skin disorder in the form of ichthyosis characterized by innumerable keratotic plugs, resulting in a peculiar sievelike appearance. On histopathologic examination the epidermis showed a pronounced orthohyperkeratosis. The keratotic plugs seemed to emerge from the infundibular region of hair follicles. Immunohistochemical characterization revealed a normal keratin and filaggrin expression. Oral treatment with isotretinoin resulted in a reduction of the hyperkeratosis. Because we could not find any previously reported similar case, we propose the new name “ichthyosis cribriformis,” which means “sievelike ichthyosis.”

The full text of this article is available in PDF format.

 Funding sources: None.
 Conflicts of interest: None declared.



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