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Journal of the American Academy of Dermatology
Volume 63, n° 5
pages 852-858 (novembre 2010)
Doi : 10.1016/j.jaad.2009.11.688

P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma

Rossitza Lazova, MD a, , Iliana Tantcheva-Poor, MD b, Alicia C. Sigal, MD a
a Department of Dermatology at Yale University School of Medicine, New Haven, Connecticut 
b Department of Dermatology, University of Cologne, Cologne, Germany 

Correspondence to: Rossitza Lazova, MD, Department of Dermatology, Yale University School of Medicine, PO Box 208059, 15 York St, LMP 5031, New Haven, CT 06520-8059.

Spindle cell melanoma (SCM) including desmoplastic melanoma (DM) is a rare variant of malignant melanoma that may present diagnostic difficulties particularly when staining with S100 is negative, weak, focal, or a combination of these. Conventional melanocytic markers in SCM are usually negative.


We sought to compare the staining of p75 nerve growth factor receptor (NGF-R) and S100 in SCMs.


We evaluated the staining of p75 NGF-R and S100 in 13 cases of SCMs: 3 SCMs without desmoplasia, 5 pure DMs, and 5 combined DMs with a conventional component.


Staining with p75 NGF-R was positive in 13 of 13 (100%) cases of SCMs. In 3 cases the intensity of staining and the percentage of cells staining with this marker were greater than those with S100. One case of SCM was negative for S100 but demonstrated strong expression of p75 NGF-R. One case was focally and weakly positive with S100 but expressed strong positive staining with p75 NGF-R. Absence of staining with p75 NGF-R was noted in the conventional round cell component of two of 5 (40%) combined DMs whereas the same areas were strongly positive for human melanoma black (HMB)-45 and Melan-A. In 5 of 5 (100%) cases of combined DMs the desmoplastic component stained positive with p75 NGF-R, demonstrating an inverse relationship with the staining of conventional melanocytic markers.


Small study size was a limitation.


p75 NGF-R exhibits superior staining characteristics and greater sensitivity in identifying SCM and DMs than S100. P75 NGF-R may be a useful diagnostic and ancillary stain in addition to S100.

The full text of this article is available in PDF format.

Key words : desmoplastic, desmoplastic melanoma, nerve growth factor receptor, p75, spindle cell melanoma

Abbreviations used : DM, HMB, NGF-R, SCM

 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.

© 2009  American Academy of Dermatology, Inc.@@#104156@@
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