Article

2 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates



Journal of the American Academy of Dermatology
Volume 63, n° 5
pages 852-858 (novembre 2010)
Doi : 10.1016/j.jaad.2009.11.688
Dermatopathology

P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma
 

Rossitza Lazova, MD a, , Iliana Tantcheva-Poor, MD b, Alicia C. Sigal, MD a
a Department of Dermatology at Yale University School of Medicine, New Haven, Connecticut 
b Department of Dermatology, University of Cologne, Cologne, Germany 

Correspondence to: Rossitza Lazova, MD, Department of Dermatology, Yale University School of Medicine, PO Box 208059, 15 York St, LMP 5031, New Haven, CT 06520-8059.
Abstract
Background

Spindle cell melanoma (SCM) including desmoplastic melanoma (DM) is a rare variant of malignant melanoma that may present diagnostic difficulties particularly when staining with S100 is negative, weak, focal, or a combination of these. Conventional melanocytic markers in SCM are usually negative.

Objective

We sought to compare the staining of p75 nerve growth factor receptor (NGF-R) and S100 in SCMs.

Methods

We evaluated the staining of p75 NGF-R and S100 in 13 cases of SCMs: 3 SCMs without desmoplasia, 5 pure DMs, and 5 combined DMs with a conventional component.

Results

Staining with p75 NGF-R was positive in 13 of 13 (100%) cases of SCMs. In 3 cases the intensity of staining and the percentage of cells staining with this marker were greater than those with S100. One case of SCM was negative for S100 but demonstrated strong expression of p75 NGF-R. One case was focally and weakly positive with S100 but expressed strong positive staining with p75 NGF-R. Absence of staining with p75 NGF-R was noted in the conventional round cell component of two of 5 (40%) combined DMs whereas the same areas were strongly positive for human melanoma black (HMB)-45 and Melan-A. In 5 of 5 (100%) cases of combined DMs the desmoplastic component stained positive with p75 NGF-R, demonstrating an inverse relationship with the staining of conventional melanocytic markers.

Limitations

Small study size was a limitation.

Conclusion

p75 NGF-R exhibits superior staining characteristics and greater sensitivity in identifying SCM and DMs than S100. P75 NGF-R may be a useful diagnostic and ancillary stain in addition to S100.

The full text of this article is available in PDF format.

Key words : desmoplastic, desmoplastic melanoma, nerve growth factor receptor, p75, spindle cell melanoma

Abbreviations used : DM, HMB, NGF-R, SCM



 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.



© 2009  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline
You can move this window by clicking on the headline