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Journal of the American Academy of Dermatology
Volume 63, n° 5
pages 866-881 (novembre 2010)
Doi : 10.1016/j.jaad.2009.10.048
Reviews

Wound healing in the 21st century
 

Stephan Schreml, MD a, , Rolf-Markus Szeimies, MD, PhD a, Lukas Prantl, MD, PhD b, Michael Landthaler, MD, PhD a, Philipp Babilas, MD, PhD a
a Department of Dermatology, Regensburg University Hospital, Regensburg, Germany 
b Department of Plastic Surgery, Regensburg University Hospital, Regensburg, Germany 

Reprint requests: Stephan Schreml, MD, Department of Dermatology, Regensburg University Hospital, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Abstract

Delayed wound healing is one of the major therapeutic and economic issues in medicine today. Cutaneous wound healing is an extremely well-regulated and complex process basically divided into 3 phases: inflammation, proliferation, and tissue remodeling. Unfortunately, we still do not understand this process precisely enough to give direction effectively to impaired healing processes. There have been many new developments in wound healing that provide fascinating insights and may improve our ability to manage clinical problems. Our goal is to acquaint the reader with selected major novel findings about cutaneous wound healing that have been published since the beginning of the new millennium. We discuss advances in areas such as genetics, proteases, cytokines, chemokines, and regulatory peptides, as well as therapeutic strategies, all set in the framework of the different phases of wound healing.

The full text of this article is available in PDF format.

Key words : cellular, molecular, novel findings, signal transduction, pH value, skin wound

Abbreviations used : AGE, Cyr61, ECM, EGF, ERK, FGF, HGF, HSP, IL, IL-1ra, KGF, LacZ, LL-37, MMP, mTOR, NF, NPY, Nramp1, Nrf, PI3K, RE, Shh, SPARC, TF, TGF, TIMP, TLR, VEGF



 Supported by grants of the German Research Foundation (Deutsche Forschungsgemeinschaft DFG, BA 3410/3-1) and the Novartis Foundation (S.S., Novartis Graduate Scholarship).
 Conflicts of interest: None declared.



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