Racial differences in mycosis fungoides: A retrospective study with a focus on eosinophilia - 15/05/13
Reprint requests: Ginette A. Hinds, MD, Johns Hopkins Bayview Medical Center, Mason F. Lord Bldg Center Tower, Suite 2500, 5200 Eastern Ave, Baltimore, MD 21224.Abstract |
Background |
Mycosis fungoides (MF) is often associated with eosinophilia and portends a poorer prognosis. MF is more common in blacks and follows a more aggressive course compared with whites.
Objective |
We further elucidate racial differences between blacks and whites with MF, focusing on blood eosinophilia.
Methods |
The records of 345 patients with MF were reviewed for demographic, clinical, and pathologic data and evaluated by analysis of variance.
Results |
The average age at diagnosis for blacks was 45 years and was 55 years for white patients (P < .001). In the cohorts of patients with and without blood eosinophilia, the average maximum blood eosinophil count had a greater range in blacks. Independent of race, blood eosinophilia was predictive of more advanced disease (P < .0001), increased number of treatment types (P < .002), and less responsiveness to treatment (P < .0006).
Limitations |
This was a retrospective study at a single institution.
Conclusions |
These differences observed in eosinophil values may highlight disparities in MF diagnosis or a difference in pathophysiology between races.
Le texte complet de cet article est disponible en PDF.Key words : black, cutaneous T-cell lymphoma, eosinophilia, ethnic skin, mycosis fungoides, race
Abbreviations used : CTCL, MF, SS
Plan
| Funding sources: None. |
|
| Conflicts of interest: None declared. |
Vol 68 - N° 6
P. 967-971 - juin 2013 Retour au numéro
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