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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le samedi 18 mai 2013
Doi : 10.1016/j.jaad.2013.04.028
Zinc deficiency and its management in the pediatric population: A literature review and proposed etiologic classification

Michael D. Corbo, MD a, , Joseph Lam, MD, FRCPC b
a Department of Dermatology, University of Toronto, Toronto, Ontario 
b Departments of Pediatrics and Dermatology, University of British Columbia, Vancouver, British Columbia, Canada 

Correspondence to: Michael D. Corbo, MD, Department of Dermatology, University of Toronto, 2075 Bayview Ave, Suite M1-700, Toronto, Ontario M4N 3M5, Canada.

Zinc is a trace element essential to the gastrointestinal, immune, integumentary, reproductive, and central nervous systems. Zinc deficiency is prevalent in many areas of the world and is a diagnostically challenging condition. Cutaneous manifestations typically occur in moderate to severe zinc deficiency and present as alopecia and dermatitis in the perioral, acral, and perineal regions. Zinc deficiency is a potentially fatal disease process. The aim of this review is to focus on the cutaneous manifestations, diagnosis, and treatment of zinc deficiency in children, and to propose an etiologic classification system.

The full text of this article is available in PDF format.

Key words : acrodermatitis enteropathica, micronutrients, pediatric, zinc absorption, zinc deficiency, zinc metabolism

Abbreviations used : AE, IL, MMP, NF, ROS, SLC

 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.

© 2013  American Academy of Dermatology, Inc.@@#104156@@
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