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Journal Français d'Ophtalmologie
Volume 36, n° 5
pages 431-434 (mai 2013)
Doi : 10.1016/j.jfo.2012.11.005
Received : 14 Mars 2012 ;  accepted : 11 November 2012
Intravitreal injection of anti-VEGF and diagnosis of primary intraocular central nervous system lymphoma
Injections intravitréennes d’anti-VEGF et diagnostic de lymphome oculocérébral

Figure 1

Figure 1 : 

Photography of the anterior segment of the right eye showing very mild inflammation.

Figure 2

Figure 2 : 

Fluorescein angiography (FA) and optical coherence tomography (OCT) of the right eye demonstrating that classic choroidal neovascularization (CNV) is still active after two intravitreous injections of ranibizumab: a: late-phase FA showing the intense leakage of the classic CNV and numerous punctate retinal infiltrates related to primary intraocular lymphoma. White arrow indicates the direction of the OCT-scan below; b: horizontal OCT-scan showing a discrete, elevated, hyperreflective, subretinal lesion above the retinal pigment epithelium corresponding to CNV with persistent subretinal fluid at its periphery (arrow).

Figure 3

Figure 3 : 

Brain MRI showing multiple contrast-enhancing lesions demonstrating the involvement of the temporal, occipital and frontal lobes by intraocular central nervous system (CNS) lymphoma.

Figure 4

Figure 4 : 

Cytological examination from undiluted vitreous showing rare atypical lymphoid cells with basophilic cytoplasm and large prominent irregular nuclei corresponding to malignant B-cell lymphoma cells.

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