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Archives of cardiovascular diseases
Volume 106, n° 4
pages 196-201 (avril 2013)
Doi : 10.1016/j.acvd.2013.01.004
Received : 24 July 2012 ;  accepted : 10 January 2013
Effects of enalapril on the expression of cardiac angiotensin-converting enzyme and angiotensin-converting enzyme 2 in spontaneously hypertensive rats
Effets de l’énalapril sur l’expression de l’enzyme de conversion de l’angiotensine 1 et 2 chez des rats spontanément hypertendus
 

Figure 1




Figure 1 : 

Cardiac angiotensin-converting enzyme (ACE) 2 and ACE messenger ribonucleic acid (mRNA) in the Wistar Kyoto rat group (W), the spontaneously hypertensive rat (SHR) control group (C) and the SHR enalapril group (E). ACE mRNA elevated and ACE2 mRNA decreased in SHRs (P <0.05). Enalapril significantly reduced the expression of ACE mRNA and elevated the level of ACE2 mRNA (P <0.05). Data were analyzed with analysis of variance and pairwise comparisons. P -values showed significance among the pairwise comparisons. * P <0.05 vs. C. Δ P <0.05 vs. W.


Figure 2




Figure 2 : 

Effects of enalapril on angiotensin-converting enzyme (ACE) 2 and ACE proteins. ACE protein elevated and ACE2 protein decreased in SHRs (P <0.05). Enalapril significantly decreased the expression of ACE protein (P <0.05), yet had no statistically significant impact on the level of ACE2 protein (P >0.05). C: spontaneously hypertensive rat control group; W: Wistar Kyoto rat group; E: enalapril group. Data were analyzed with analysis of variance and pairwise comparisons. P -values showed significance among the pairwise comparisons. * P <0.05 vs. C. Δ P <0.05 vs. W.

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