Article

PDF
Access to the PDF text
Advertising


Free Article !

Archives of cardiovascular diseases
Volume 106, n° 4
page 247 (avril 2013)
Doi : 10.1016/j.acvd.2013.03.008
Abstracts

Echocardiographic predictors of cardiovascular events in a population of subjects aged over 65years: Preliminary results
 

C. Van Der Vynckt, J. Joffre, S. Lang, S. Ederhy, D. Arangalage, N. Haddour, L. Soulat-Dufour, S. Adavane, F. Boccara, A. Cohen
 Hôpital St Antoine, Paris, France 

Background .– The left atrium is a marker of clinical and subclinical cardiovascular disease. The additional role of left atrial (LA) and left ventricular (LV) speckle-derived strain parameters has not been assessed in an aged population, included in a prospective cohort of subjects with a long-term follow-up.

Objectives .– To determine whether LV and LA global strain is a predictor of cardiovascular events in a population, beyond other clinical and morphological characteristics.

Methods and results .– The COVADIS study aims to analyse the relationship between cardiac and cerebral ageing, studied multidimensionnally (biology, MRI, echocardiography), and the determinants of cognitive impairment. We performed a complete echocardiographic examination and measured LV and LA peak systolic global longitudinal strain using a semi-automatic speckle tracking software in 85 subjects aged over 65years. The endpoint was a composite cardiovascular (CV) criterion of coronary event, stroke or death. In univariate analysis, the main predictors of CV events are depicted in the table. The Kaplan-Meier curves show that LA area>20cm2 was associated with a higher risk of CV events. Multivariate analysis could not be performed due to the low number of CV events. LV and LA peak systolic global longitudinal strains were not associated with CV events.

Conclusion .– These early and preliminary results confirm the feasibility and reproducibility of deformation measurements in this population, although not associated with CV events, and is currently extended to a cohort of over 2000 patients.



ParametersUnivariate analysis HR (95% CI)PAge, years1.04 (0.90–1.20)0.596Gender, female0.13(0.03–0.63)0.011LA area>20cm29.90 (2.37–41.41)0.002EDV indexed1.06 (1.00–1.13)0.051LVEF (biplane)0.92 (0.83–1.00)0.044

Parameters Univariate analysis HR (95% CI) P  
Age, years 1.04 (0.90–1.20) 0.596 
Gender, female 0.13(0.03–0.63) 0.011 
LA area>20cm2 9.90 (2.37–41.41) 0.002 
EDV indexed 1.06 (1.00–1.13) 0.051 
LVEF (biplane) 0.92 (0.83–1.00) 0.044 


Top of the page

© 2013  Published by Elsevier Masson SAS.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline
You can move this window by clicking on the headline
@@#110903@@