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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le samedi 25 mai 2013
Doi : 10.1016/j.jaad.2013.03.029
The efficacy of pulsed dye laser treatment for inflammatory skin diseases: A systematic review

Angelina Erceg, MD, PhD a, , Elke M.J. G. de Jong, MD, PhD b, Peter C.M. van de Kerkhof, MD, PhD b, Marieke M.B. Seyger, MD, PhD b
a Department of Dermatology, Amphia Hospital Breda, Breda, The Netherlands 
b Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands 

Reprint requests: Angelina Erceg, MD, PhD, Department of Dermatology, Amphia Hospital, Molengracht 21, PO Box 90158, 4818 CK Breda, The Netherlands.

The position of the pulsed dye laser (PDL) in the treatment of inflammatory skin diseases is still unclear. Evidence-based recommendations are lacking.


We sought to systematically review all available literature concerning PDL treatment for inflammatory skin diseases and to propose a recommendation.


We searched for publications dated between January 1992 and August 2011 in the database PubMed. All studies reporting on PDL treatment for an inflammatory skin disease were obtained and a level of evidence was determined.


Literature search revealed 52 articles that could be included in this study. The inflammatory skin diseases treated with PDL consisted of: psoriasis, acne vulgaris, lupus erythematodes, granuloma faciale, sarcoidosis, eczematous lesions, papulopustular rosacea, lichen sclerosis, granuloma annulare, Jessner lymphocytic infiltration of the skin, and reticular erythematous mucinosis. The efficacy of PDL laser treatment for these inflammatory skin diseases was described and evaluated.


Most conclusions formulated are not based on randomized controlled trials.


PDL treatment can be recommended as an effective and safe treatment for localized plaque psoriasis and acne vulgaris (recommendation grade B). For all other described inflammatory skin diseases, PDL seems to be promising, although the level of recommendation did not exceed level C.

The full text of this article is available in PDF format.

Key words : inflammatory, pulsed dye laser, skin diseases, treatment

Abbreviations used : CDLE, GF, LOE, LT, PDL, RCT, SCLE, SLE, UVB

 Funding sources: None.
 Conflicts of interest: None declared.

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