6 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

Biomedicine and Preventive Nutrition
Volume 3, n° 2
pages 151-157 (avril 2013)
Doi : 10.1016/j.bionut.2012.12.006
Received : 9 November 2012 ;  accepted : 12 December 2012
Immunomodulatory activity of isoflavones isolated from Iris kashmiriana : Effect on T-lymphocyte proliferation and cytokine production in Balb/c mice

Nighat Nazir
Department of Chemistry, Islamia College of Science and Commerce, Hawal, Srinagar 190002, J&K, India 


This study deals with the evaluation of immunomodulatory action of a new isoflavone isonigricin (1) and first report isoirisolidone (2) isolated from rhizomes of Iris kashmiriana. Flowcytometric method was employed to study their effect on production of T-lymphocytes (CD4+ and CD8+ T-cells) and T-cell cytokines (IL-2, IL-4 and IFN-γ) in a dose-dependant manner. Drugs at doses of 0.025 to 0.8mg/kg per oral dose showed compound 1 to possess immunosuppressant activity on T-cells as well as cytokines, while compound 2 acted as immunostimulator for both cells and cytokines. However, their methylated products viz. 1OMe and 2OMe exhibited stimulatory effect on interleukins under study and suppressive effect on production of T-lymphocytes and IFN-γ. The oral LD50 in mice was observed to be more than 200mg/kg body weight. Such a difference in their activity is the manifestation of the position and nature of substituents present on isoflavonoidal skeleton and demonstrates the potential of these isolates as prospective immunomodulatory agents.

The full text of this article is available in PDF format.

Keywords : Iris kashmiriana , Iridaceae, Isoflavones, Cytokines, Immunomodulators, Flowcytometry

© 2013  Published by Elsevier Masson SAS.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline