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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le jeudi 11 juillet 2013
Doi : 10.1016/j.jaad.2013.05.015
accepted : 19 May 2013
Acquired reactive digital fibroma: A clinicopathologic report of 5 cases of a new entity
 

Jose A. Plaza, MD a, , Saul Suster, MD a, Victor G. Prieto, MD, PhD c, Martin Sangueza, MD b
a Department of Pathology, Division of Dermatopathology at the Medical College of Wisconsin, Milwaukee, Wisconsin 
b Department of Pathology, Division of Dermatopathology, Hospital Obrero, La Paz, Bolivia 
c Department of Pathology, Division of Dermatopathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 

Reprint requests: Jose A. Plaza, MD, Department of Pathology, Froedtert and Medical College, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226.
Abstract
Background

Fibroblastic proliferations in the dermis comprise a heterogeneous group of disorders that can pose diagnostic challenges.

Objective

We sought to study the clinicopathologic features of this tumor.

Methods

We reviewed the clinicopathologic features of 5 unusual mesenchymal tumors of the digits that, to our knowledge, correspond to an entity not previously described.

Results

The patients were 5 men. All cases were located in the digits and were associated with history of trauma. Histopathologically, the neoplasms were located mainly in the reticular dermis. The tumors consisted of solitary nodules composed of fascicles of benign-appearing spindle cells devoid of cytologic atypia. The spindle cells formed short fascicles arranged in a haphazard manner. On immunohistochemistry, the tumor cells expressed vimentin and in 2 cases, CD34. The tumor cells were negative for smooth muscle actin (SMA), desmin, h-caldesmon, epithelial membrane antigen (EMA), S100, CD68, CD99, and beta-catenin.

Limitations

Only 5 cases were studied.

Conclusions

Awareness of this entity is of importance to avoid misdiagnosis with other conditions. Based on the immunohistochemical pattern, we believe that these tumors are fibroblastic in origin. The peculiar gross appearance and location of the lesions is clinically quite distinctive and may lead to confusion with other neoplastic and reactive processes.

The full text of this article is available in PDF format.

Key words : acquired neoplasms of digits, acquired reactive digital fibroma of digits, digital fibroma, fibroblastic tumor of digits, reactive digital fibroma, reactive fibroma of digits



 Funding sources: None.
 Conflicts of interest: None declared.



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