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Archives of cardiovascular diseases
Volume 106, n° 6-7
pages 382-393 (juin 2013)
Doi : 10.1016/j.acvd.2013.04.009
Received : 23 April 2013 ;  accepted : 23 April 2013
Management of major bleeding complications and emergency surgery in patients on long-term treatment with direct oral anticoagulants, thrombin or factor-Xa inhibitors: Proposals of the Working Group on Perioperative Haemostasis (GIHP) – March 2013
Prise en charge des complications hémorragiques graves et de la chirurgie en urgence chez les patients recevant un anticoagulant oral anti-IIa ou anti-Xa direct : propositions du Groupe d’Intérêt en hémostase périopératoire (GIHP) – mars 2013
 

Figure 1




Figure 1 : 

Support for emergency surgery in a patient treated with dabigatran (curative scheme), based on the determination of plasma concentrations. CkrCl: creatinine clearance calculated according to the formula of Cockcroft and Gault; FEIBA: activated prothrombin complex concentrate factor VIII inhibitor bypassing activity; GIHP: Working Group on Perioperative Haemostasis; PCC: prothrombin complex concentrate; rFVIIa: recombinant factor VIIa.


Figure 2




Figure 2 : 

Support for emergency surgery in a patient treated with rivaroxaban (curative scheme), based on the determination of plasma concentrations. FEIBA: activated prothrombin complex concentrate factor VIII inhibitor bypassing activity; GIHP: Working Group on Perioperative Haemostasis; PCC: prothrombin complex concentrate; rFVIIa: recombinant factor VIIa.


Figure 3




Figure 3 : 

Support for emergency surgery in a patient treated with dabigatran (curative scheme), based on the determination of prothrombin time (PT)/activated partial thromboplastin time (aPTT). FEIBA: activated prothrombin complex concentrate factor VIII inhibitor bypassing activity; GIHP: Working Group on Perioperative Haemostasis; PCC: prothrombin complex concentrate; rFVIIa: recombinant factor VIIa.


Figure 4




Figure 4 : 

Support for emergency surgery in a patient treated with rivaroxaban (curative scheme), based on the determination of prothrombin time (PT)/activated partial thromboplastin time (aPTT). FEIBA: activated prothrombin complex concentrate factor VIII inhibitor bypassing activity; GIHP: Working Group on Perioperative Haemostasis; PCC: prothrombin complex concentrate; rFVIIa: recombinant factor VIIa.


Figure 5




Figure 5 : 

Support for severe bleeding in a patient treated with dabigatran or rivaroxaban (curative scheme), on the basis of the determination of the drug concentration. FEIBA: activated prothrombin complex concentrate factor VIII inhibitor bypassing activity; GIHP: Working Group on Perioperative Haemostasis; PCC: prothrombin complex concentrate; rFVIIa: recombinant factor VIIa.


Figure 6




Figure 6 : 

Management of severe bleeding in a patient treated with dabigatran or rivaroxaban (curative scheme), based on the determination of prothrombin time/activated partial thromboplastin time. FEIBA: activated prothrombin complex concentrate factor VIII inhibitor bypassing activity; GIHP: Working Group on Perioperative Haemostasis; PCC: prothrombin complex concentrate; rFVIIa: recombinant factor VIIa.

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