2 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mercredi 31 juillet 2013
Doi : 10.1016/j.jaad.2013.05.030
accepted : 26 May 2013
Diffuse capillary malformation with overgrowth: A clinical subtype of vascular anomalies with hypertrophy

Margaret S. Lee, MD, PhD a, , Marilyn G. Liang, MD a, John B. Mulliken, MD b
a Dermatology Program, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts 
b Department of Plastic and Oral Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts 

Reprint requests: Margaret S. Lee, MD, PhD, Dermatology Program, Boston Children's Hospital, 300 Longwood Ave, Fegan 6, Boston, MA 02115.

Categorization of vascular anomalies with overgrowth is evolving rapidly with the aid of massively parallel genomic sequencing; however, accurate clinical diagnosis is still essential. We identified a group of patients with an extensive, diffuse, reticulate capillary malformation (CM) and variable hypertrophy without major complications.


We sought to study a subset of patients with diffuse CM to better define prognosis and management.


Chart review identified 73 patients with diffuse CM who did not fit the criteria for known disorders with CM and/or overgrowth.


Soft-tissue or bony overgrowth did not correlate with location, morphology, or intensity of the vascular stain. Patients required periodic follow-up to monitor for leg length discrepancy. They were found to exhibit normal neurologic development and proportionate overgrowth rather than progressive, disproportionate asymmetry or vascular complications.


This retrospective review was limited to observations documented at clinic visits; these patients require long-term assessment. Further studies are necessary to accurately assess Wilms tumor risk and clinical outcomes in older adults.


We propose the term “diffuse capillary malformation with overgrowth” to designate this extensive reticular vascular staining with proportionate overgrowth. We differentiate diffuse capillary malformation with overgrowth from other disorders with CM and hypertrophy.

The full text of this article is available in PDF format.

Key words : capillary malformation, hemihyperplasia, hemihypertrophy, hyperplasia, hypertrophy, overgrowth

Abbreviations used : CLOVES, CLVM, CM, CMTC, DCMO, KTS, LM, M-CM, VM

 Funding sources: None.
 Conflicts of interest: None declared.

© 2013  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline