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Journal of the American Academy of Dermatology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mercredi 31 juillet 2013
Doi : 10.1016/j.jaad.2013.05.030
accepted : 26 May 2013
Diffuse capillary malformation with overgrowth: A clinical subtype of vascular anomalies with hypertrophy
 

Margaret S. Lee, MD, PhD a, , Marilyn G. Liang, MD a, John B. Mulliken, MD b
a Dermatology Program, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts 
b Department of Plastic and Oral Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts 

Reprint requests: Margaret S. Lee, MD, PhD, Dermatology Program, Boston Children's Hospital, 300 Longwood Ave, Fegan 6, Boston, MA 02115.
Abstract
Background

Categorization of vascular anomalies with overgrowth is evolving rapidly with the aid of massively parallel genomic sequencing; however, accurate clinical diagnosis is still essential. We identified a group of patients with an extensive, diffuse, reticulate capillary malformation (CM) and variable hypertrophy without major complications.

Objective

We sought to study a subset of patients with diffuse CM to better define prognosis and management.

Methods

Chart review identified 73 patients with diffuse CM who did not fit the criteria for known disorders with CM and/or overgrowth.

Results

Soft-tissue or bony overgrowth did not correlate with location, morphology, or intensity of the vascular stain. Patients required periodic follow-up to monitor for leg length discrepancy. They were found to exhibit normal neurologic development and proportionate overgrowth rather than progressive, disproportionate asymmetry or vascular complications.

Limitations

This retrospective review was limited to observations documented at clinic visits; these patients require long-term assessment. Further studies are necessary to accurately assess Wilms tumor risk and clinical outcomes in older adults.

Conclusion

We propose the term “diffuse capillary malformation with overgrowth” to designate this extensive reticular vascular staining with proportionate overgrowth. We differentiate diffuse capillary malformation with overgrowth from other disorders with CM and hypertrophy.

The full text of this article is available in PDF format.

Key words : capillary malformation, hemihyperplasia, hemihypertrophy, hyperplasia, hypertrophy, overgrowth

Abbreviations used : CLOVES, CLVM, CM, CMTC, DCMO, KTS, LM, M-CM, VM



 Funding sources: None.
 Conflicts of interest: None declared.



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