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Annales de Dermatologie et de Vénéréologie
Volume 140, n° S2
pages 223-228 (novembre 2013)
Doi : 10.1016/S0151-9638(13)70138-8
Revue Panoramique de la PDT Principe, photo-sensibilisateurs, sources de lumières et indications validées en dermatologie
PDT panoramic view Principle, photosensitizers, light sources and validated indications in dermatology

N. Basset-Seguin
 Service de Dermatologie, Hôpital Saint Louis, 1 avenue Claude Vellefaux 75475 Paris cedex 10, France 


La photothérapie dynamique (PDT) est une méthode associant l’utilisation d’un photo-sensibilisateur topique et son excitation par une lumière de longueur d’onde appropriée. Son utilisation en oncodermatologie est devenue routinière en France depuis 2006, date de la mise sur le marché du photo-sensibilisateur le plus utilisé, le méthyl ester d’ALA ou Metvixia®.


Fournir une vue panoramique des indications validées de la PDT en oncodermatologie.


Ce travail est basé sur revue de la littérature et des guidelines ou recommandations disponibles et récentes sur la PDT en dermatologie.


Les protocoles standardisés ainsi que les résultats des essais cliniques principaux sont donnés pour les trois indications majeures en dermatologie : les kératoses actiniques, les carcinomes basocellulaires superficiels et la maladie de Bowen.


La PDT a toute sa place dans la prise en charge des carcinomes superficiels ou des lésions cutanées précancéreuses multiples et son avantage majeur est l’obtention d’une cicatrisation optimale.

The full text of this article is available in PDF format.

Photodynamic therapy (PDT) combines the use of a topical sensitizer and its excitation with a light of appropriate wavelength. Its use in dermatooncology has been possible in France in 2006 when the methyl ester ALA or Metvixia® got approved.


To provide a panoramic view of validated indications of PDT in oncodermatology.


This work is based on the review of the literature as well as available guidelines or recommendation on PDT in dermatology.


Standardized protocols and results of the main clinical trials are given for the three major indications in dermatology: actinic keratosis, basal cell carcinoma and Bowen disease.


PDT has its role to play in the treatment of multiple superficial carcinomas and cutaneous precancerous lesions and its main advantage resides in its optimal healing.

The full text of this article is available in PDF format.

Mots cles : Kératoses actiniques, Carcinome basocellulaire superficiel, Maladie de Bowen, Photothérapie dynamique

Key words : Actinic keratosis, Basal cell carcinoma, Bowen's disease, Photodynamic therapy

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