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Annales de Dermatologie et de Vénéréologie
Volume 140, n° S2
pages 229-235 (novembre 2013)
Doi : 10.1016/S0151-9638(13)70139-X
Photothérapie dynamique en dermatologie, autres indications et perspectives
Photodynamic therapy in dermatology other indications and perspectives
 

Ch. Bédane
 Service de Dermatologie, Hôpital Dupuytren, 2 avenue Martin Luther King 87042 Limoges, France 

Résumé

Les principales indications de la PDT en dermatologie sont les tumeurs superficielles, kératoses actiniques, maladies de Bowen et carcinomes baso-cellulaires superficiels. Ces trois indications font l’objet d’une AMM depuis 2006 en France sous réserve d’une sensibilisation par méthyl-aminolevulinate et d’une illumination en lumière rouge.

À côté de ces 3 indications reconnues, la PDT devrait progressivement trouver sa place dans l’arsenal thérapeutique de nombreuses dermatoses inflammatoires et peut-être d’autres pathologies tumorales dans le cadre de traitements combinés.

La gestion des phénomènes douloureux représente la principale difficulté à résoudre pour les surfaces étendues. Elle repose essentiellement sur des procédures de refroidissement en cours de traitement. L’un des aspects les plus intéressants de la PDT est l’absence d’effets secondaires retardés et une cicatrisation de qualité particulièrement rapide.

The full text of this article is available in PDF format.
Summary

PDT licensed indications in dermatology are actinic keratosis, Bowen's disease and superficial basal cell carcinomas. Skin tumors are sensitized by methyl aminomevulinate then illuminated with red light.

Beyond these indication PDT is now widely used for the treatment of various others skin tumors and infectious or inflammatory skin disorders.

PDT treatment of large areas can induce intense pain. Optimising PDT treatment needs to optimize pain control. Freezing or cooling procedure is the best way to decrease pain. The most interesting aspects of PDT is the absence of severe delayed adverse events and an optimal healing.

The full text of this article is available in PDF format.

Mots clés : Photothérapie dynamique, Maladie de Paget extramammaire, Acné, Lymphomes cutanés, Photorejuvénation

Keywords : Photodynamic therapy, Extramammary Paget disease, Acne, Cutaneous lymphomas, Photorejuvanation




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