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Joint Bone Spine
Volume 80, n° 6
pages 626-631 (décembre 2013)
Doi : 10.1016/j.jbspin.2013.03.005
accepted : 7 Mars 2013
Association of microRNAs genes polymorphisms with rheumatoid arthritis in Egyptian female patients

Amal S. El-Shal a, , 1 , Nader M. Aly a, Sahar M. Abdel Galil b, Mohamed A. Moustafa c, Wael A. Kandel d
a Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt 
b Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt 
c Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt 
d Orthopedic Surgery Department, Faculty of Medicine, Benha University, Benha, Egypt 

Corresponding author. Tel.: +20 1221546634; fax: +20 242135789.

To investigate whether miRNA-499 (rs3746444) and miRNA-146a (rs2910164) genes polymorphisms are independent factors for rheumatoid arthritis (RA) in Egyptians, and whether they influence disease severity and activity.


Two hundred and seventeen RA patients and 245 healthy controls were enrolled in this study. Polymorphisms of miRNA-146a and miRNA-499 genes were detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).


The miRNA-499 CT genotype was an independent factor of RA. The miRNA-499 CT, CC genotypes and C allele frequencies were significantly increased in erosive RA group. Moreover, the heterozygote CT had more severe and more active form of the disease compared with homozygote CC or TT. However, we did not find any significant association of miRNA-146a polymorphism with RA risk, severity, and activity.


The miRNA-499 polymorphism is an independent factor of RA, and influences disease severity and activity.

The full text of this article is available in PDF format.

Keywords : Rheumatoid arthritis, MicroRNA, Polymorphism, Egyptian population

1  The corresponding author certifies that all authors approved the entirety of the submitted material and contributed actively to the study.

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