Histopathologic clues for the diagnosis of Wiesner nevus - 14/02/14
, Yosmar Carolina Pérez-Gónzalez, MD b, Luis Requena, MD c, Heinz Kutzner, MD dAbstract |
The dermatologic hallmark of a recently described BAP1-associated cancer susceptibility syndrome is a dome-shaped nevus with distinct clinicopathological features, first delineated by Wiesner and colleagues. Here we describe the leading histopathological criteria of Wiesner nevus. Wiesner nevus is composed of various nevomelanocytic populations all showing different degrees of atypia ranging from hyperchromatic nevus cell-like to large atypical epithelioid cells. Immunohistochemically, Wiesner nevus is BAP1 negative and VE1 positive.
Le texte complet de cet article est disponible en PDF.Key words : BAP1 protein, B-raf, epithelioid and spindle cell, human, nevus, proto-oncogene proteins
Abbreviations used : BAP1, BRAF
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 70 - N° 3
P. 549-554 - mars 2014 Retour au numéro
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