Increased serum levels of interleukin 33 in patients with atopic dermatitis - 16/04/14
, Yasutaro Okuzawa, MD, Koji Masuda, MD, PhD, Norito Katoh, MD, PhDAbstract |
Background |
Interleukin (IL)-33 is a new member of the IL-1 cytokine family and a promoter of T helper type 2 (Th2) inflammation. IL-33 may be involved in the pathogenesis of atopic dermatitis (AD), but its relationship with disease severity, laboratory markers, and eruption types in patients with AD are unclear.
Objective |
The aim of this study was to quantify serum IL-33 levels in patients with AD and to examine relationships with disease severity, laboratory markers, and eruption types.
Methods |
Serum IL-33 was measured by enzyme-linked immunosorbent assay in patients with AD, chronic idiopathic urticaria, and psoriasis and in healthy control subjects.
Results |
Serum levels of IL-33 were significantly higher in patients with AD compared with those in patients with urticaria and psoriasis and in healthy control subjects, and were correlated with the disease severity of AD. IL-33 levels were also significantly correlated with excoriation and xerosis scores, but not with blood eosinophilia, serum IgE, serum thymus and activation-related chemokine, and serum lactate dehydrogenase. Elevated IL-33 levels were significantly reduced after improvement of skin lesions by drug treatment.
Limitation |
A limitation in the study was the small number of subjects.
Conclusion |
Our results suggest that IL-33 released from mechanically injured or barrier-disrupted skin may increase inflammation in AD.
Le texte complet de cet article est disponible en PDF.Key words : atopic dermatitis, excoriation, inflammation, interleukin 33, psoriasis, urticaria, xerosis
Abbreviations used : AD, EASI, IL
Plan
| Supported in part by a grant from the Japanese Ministry of Education, Science, Sports, and Culture (Drs Tamagawa-Mineoka and Katoh). |
|
| Conflicts of interest: None declared. |
Vol 70 - N° 5
P. 882-888 - mai 2014 Retour au numéro
Article précédent
- Patient perspectives in the management of psoriasis: Results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey
- Mark G. Lebwohl, Hervé Bachelez, Jonathan Barker, Giampiero Girolomoni, Arthur Kavanaugh, Richard G. Langley, Carle F. Paul, Lluís Puig, Kristian Reich, Peter C.M. van de Kerkhof
- Association of lichen planopilaris with thyroid disease: A retrospective case-control study
- Natasha Atanaskova Mesinkovska, Nikoleta Brankov, Melissa Piliang, Angela Kyei, Wilma F. Bergfeld
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?