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Biomedicine and Preventive Nutrition
Volume 4, n° 2
pages 121-129 (avril 2014)
Doi : 10.1016/j.bionut.2013.08.004
Received : 5 July 2013 ;  accepted : 9 August 2013
Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei
 

Allisson Jhonathan Gomes Castro a, Luiza Sheyla E.P. Will Castro a, Marília S. Nascimento Santos a, Monique G.C. Faustino a, Thuane S. Pinheiro a, Celina M.P. Guerra Dore a, Iuri G. Baseia b, Edda Lisboa Leite a,
a Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte (UFRN), Av. Sen. Salgado Filho 3000, Lagoa Nova, 59072-940 Natal, Brazil 
b Department of Botanic, Federal University of Rio Grande do Norte (UFRN), Av. Sen. Salgado Filho, 3000, Lagoa Nova, Natal, Brazil 

Corresponding author. Tel.: +55 31 84 3215 3415; fax: +55 31 84 3211 9208.
Abstract

Extract rich in glucans from the Caripia montagnei mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and parecoxib. Agonists of PPARα showed a value of 90.8±10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9±7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in leukocyte migration, in addition to modest nitric oxide production. The polymer antiangiogenic activity showed a high inhibiting concentration of 1000μg/egg. This study also investigated total antioxidant activity (57±0.3%), reducing power (37.6±0.16), and lipid peroxidation (84±0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0±0.01% (1mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from Caripia montagnei has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.

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Keywords : Caripia montagnei , Polysaccharides, Glucans, Antioxidant, Angiogenesis, Anti-inflammatory




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