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Journal of the American Academy of Dermatology
Volume 71, n° 1
pages 11.e1-11.e7 (juillet 2014)
Doi : 10.1016/j.jaad.2014.01.879
Continuing Medical Education

Proactive infectious disease approach to dermatologic patients who are taking tumor necrosis factor–alfa antagonists : Part II. Screening for patients on tumor necrosis factor–alfa antagonists
 

Lisa M. Chirch, MD a, Philip R. Cataline, MD a, Kevin D. Dieckhaus, MD a, Jane M. Grant-Kels, MD b,
a Department of Medicine, Division of Infectious Diseases, University of Connecticut Health Center, Farmington, Connecticut 
b Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut 

Correspondence to: Jane M. Grant-Kels, MD, University of Connecticut Health Center, Department of Dermatology, 21 South Rd, Farmington, CT 06032.
Abstract

Tumor necrosis factor–alfa levels are linked to disease severity in patients with inflammatory conditions, such as psoriasis. Inhibitors of this cytokine are commonly used with significant success in the treatment of such inflammatory disorders. Their use, however, can be plagued by infectious complications. An awareness of potential infections associated with these therapies is critical in order to maximize preventive efforts both before and during therapy. This review provides a guide for dermatologists caring for patients in need of this type of biologic therapy to preemptively address the infectious risks. Part II of this continuing medical education article reviews recommended screening methods for patients undergoing evaluations for tumor necrosis factor inhibitor therapy for psoriasis or other dermatologic diseases, and discusses possible prophylactic strategies to use, including the appropriate use of immunizations.

The full text of this article is available in PDF format.

Key words : biologic therapy, immunizations, opportunistic infection, psoriasis, tumor necrosis factor



 Funding sources: None.
 Conflicts of interest: None declared.



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